1. PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY
by HOWELL 
Price: USD 164.14
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Description: Very Good. ISBN 030644027x 9780306440274 [US] 

2. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Editor Stephen B. Howell 
Price: USD 16.69
Dealer: Biblio, Ergodebooks
Description: Springer, Date: 1992-02-29. Hardcover. Good. 1992. Springer ISBN 030644027X 9780306440274 [US] 

3. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell Stephen B. ed. 
Price: USD 8.90
Dealer: Biblio, Zubal Books
Description: Plenum Press, Date: 1992. 545 pp., Hardcover, previous owner's name to front free endpaper else very good. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country. 1992. Plenum Press ISBN 030644027X 9780306440274 [US] 

4. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Stephen B. Howell 
Price: USD 351.32
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Description: Hard Cover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; The Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. ISBN 030644027x 9780306440274 [GB] 

5. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy [Hardcover ]
Price: USD 319.30
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Description: ISBN10: 030644027X, ISBN13: 9780306440274, [publisher: Springer] Hardcover [Bayonne, NJ, U.S.A.] [Publication Year: 1992]  

6. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell, Stephen B (Editor) 
Price: USD 309.99
Dealer: Alibris
Description: New York, NY Springer 1992 1991 ed. Hard cover New. Sewn binding. Cloth over boards. 546 p. Contains: Unspecified. 

7. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell, Stephen B (Editor) 
Price: USD 42.60
Dealer: Alibris, Bonita via Alibris
Description: Springer 1992 1991 ed. hardcover Good Access codes and supplements are not guaranteed with used items. May be an ex-library book. 

8. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell, Stephen B (Editor) 
Price: USD 339.18
Dealer: Alibris, ShopSpell via Alibris
Description: New York, NY Springer 1992 1991 ed. Hard cover New. Sewn binding. Cloth over boards. 546 p. Contains: Unspecified. 

9. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell, Stephen B., Ed 
Price: USD 8.90
Dealer: Alibris, Zubal Books via Alibris
Description: Plenum Press 1992 1991 ed. Hard cover 545 pp., Hardcover, previous owner's name to front free endpaper else very good. -If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country. 

10. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell, Stephen B., ed. 
Price: USD 8.90
Dealer: Abebooks, Zubal-Books, Since 1961
Description: ISBN10: 030644027X, ISBN13: 9780306440274, [publisher: Plenum Press] Hardcover 545 pp., Hardcover, previous owner's name to front free endpaper else very good. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country. [Cleveland, OH, U.S.A.] [Publication Year: 1992]  

11. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Howell 
Price: USD 175.78
Dealer: Alibris, Books International via Alibris
Description: Springer 1992 1991 ed. Hard cover New 

12. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Price: USD 344.52
Dealer: Abebooks, Lucky's Textbooks
Description: ISBN10: 030644027X, ISBN13: 9780306440274, [publisher: Springer] Hardcover [Dallas, TX, U.S.A.] [Publication Year: 1992]  

13. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Price: USD 370.72
Dealer: AbebooksUK, Mispah books
Description: ISBN10: 030644027X, ISBN13: 9780306440274, [publisher: Springer] Hardcover Like New [Redhill, SURRE, United Kingdom] [Publication Year: 1992]  

14. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Stephen B. Howell 
Price: USD 370.02
Dealer: AbebooksDE, AHA-BUCH GmbH
Description: ISBN10: 030644027X, ISBN13: 9780306440274, [publisher: Springer US] Hardcover Druck auf Anfrage Neuware - Printed after ordering - Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations. [Einbeck, Germany] [Publication Year: 1992]  

15. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
by Stephen B. Howell 
Price: USD 332.19
Dealer: ZVAB, AHA-BUCH GmbH
Description: ISBN10: 030644027X, ISBN13: 9780306440274, [publisher: Springer US] Hardcover Druck auf Anfrage Neuware - Printed after ordering - Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations. [Einbeck, Germany] [Publication Year: 1992]