San Rafael Morgan & Claypool Publishers 2010 Paperback New. 157 p. Colloquium Series on Integrated Systems Physiology . Intended for college/higher education audience.

Morgan & Claypool, Date: 2010. Paperback. New. 1st edition. 154 pages. 9.25x7.50x0.35 inches. 2010. Morgan & Claypool ISBN 1615041508 9781615041503 [GB]

Morgan & Claypool Life Science 2010 paperback Good Access codes and supplements are not guaranteed with used items. May be an ex-library book.

paperback. Good. Access codes and supplements are not guaranteed with used items. May be an ex-library book. ISBN 1615041508 9781615041503 [US]

ISBN10: 1615041508, ISBN13: 9781615041503, [publisher: Biota Publishing] Softcover nach der Bestellung gedruckt Neuware - Printed after ordering - Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major facto ...
Show/Hide image