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If I am not for myself, who will be for me? If I am not for others, what am I? And if not now, when?
Groner, Yoram (Editor), and Ito, Yoshiaki (Editor), and Liu, Paul (Editor)
USD
206.66
Alibris /Alibris
Singapore Springer 2017 2017 ed. Hard cover New. Sewn binding. Cloth over boards. 515 p. Contains: Illustrations, black & white, Illustrations, color, Tables, color. Advances in Experimental Medicine and Biology, 962.
ISBN10: 9811032319, ISBN13: 9789811032318, [publisher: Springer Nature Singapore] Hardcover Druck auf Anfrage Neuware - Printed after ordering - This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both 'gatekeepers' that modulate p53 responses and 'caretakers' that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in t ...
ISBN10: 9811032319, ISBN13: 9789811032318, [publisher: Springer Nature Singapore] Hardcover Druck auf Anfrage Neuware - Printed after ordering - This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both 'gatekeepers' that modulate p53 responses and 'caretakers' that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in t ...
Groner, Yoram (Edited by)/ Ito, Yoshiaki (Edited by)/ Liu, Paul (Edited by)/ Neil, James C. (Edited by)/ Speck, Nancy A. (Edited by)/ van Wijnen, Andre (Edited by)
USD
300.20
Revaluation Books /AbebooksUK
ISBN10: 9811032319, ISBN13: 9789811032318, [publisher: Springer] Hardcover 515 pages. 10.25x7.25x1.25 inches. In Stock. [Exeter, United Kingdom] [Publication Year: 2017]
ISBN10: 9811032319, ISBN13: 9789811032318, [publisher: Springer Verlag, Singapore, Singapore] Hardcover First Edition Hardcover. This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both gatekeepers that modulate p53 responses and caretakers that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the im ...
DISCLOSURE:
When you click on links to various merchants on this site and make a purchase, this can result in this site earning a commission at no extra cost to you. Affiliate programs and affiliations include, but are not limited to, the eBay Partner Network, Amazon and Alibris.
