Hard Cover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; The Mechanisms in Parkinson's Disease:Models and Treatments. ISBN 9533078766 9789533078762 [GB]

Intechopen 2012 Hard cover New. Sewn binding. Cloth over boards. 608 p.

IntechOpen 2/8/2012 12: 00: 00 AM Hardcover PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK.

ISBN10: 9533078766, ISBN13: 9789533078762, [publisher: Intechopen] Hardcover nach der Bestellung gedruckt Neuware - Printed after ordering - Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
[Einbeck, Germany] [Publication Year: ...
Show/Hide image