Secaucus, New Jersey: Springer Verlag, Date: 2003. Hard Cover. Very Good/No Dust Jacket. Very good copy with minor shelfwear. 2003. Springer Verlag ISBN 3540442081 9783540442080 [US]

ISBN10: 3540442081, ISBN13: 9783540442080, [publisher: Springer] Hardcover 296 pages. A Good clean copy.This book provides timely reviews of several protein complexes that regulate gene expression and chromatin dynamics. Examples of such complexes include: nucleosome assembly complexes, ATPdependent chromatin remodeling complexes, histone acetyltransferase complexes, histone deacetylase complexes, heterochromatin complexes, SMC complexes and transcription elongation complexes. These chapters will bring experts in the field up to date on several aspects of chromosome biology and will provide an exiting introduction to the field for new chromatin researchers. An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The extensive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cisacting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin ...