ISBN10: 0123739896, ISBN13: 9780123739896, [publisher: Academic Press] Hardcover Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!
[Dallas, TX, U.S.A.] [Publication Year: 2007]

ISBN10: 0123739896, ISBN13: 9780123739896, [publisher: Elsevier Science] Hardcover nach der Bestellung gedruckt Neuware - Printed after ordering - Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is ...
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Amsterdam Academic Press 2007 Hard cover New. Sewn binding. Paper over boards. 504 p. Contains: Illustrations, color, Tables, black & white, Figures.

Elsevier Science 10/16/2007 12: 00: 00 AM Hardcover PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from US in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the US.

Elsevier Science 10/16/2007 12: 00: 00 AM Hardcover New Book. Shipped from US in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the US.

Academic Pr 2007 Hardcover New 1st edition. 300 pages. 9.50x6.25x1.00 inches.

ISBN10: 0123739896, ISBN13: 9780123739896, [publisher: Academic Press 2007-10-16] Hardcover
[Wallingford, United Kingdom] [Publication Year: 2007]